Details of Microbe Species (MIC)

General Information of MIC (ID: MC1066)
  MIC Name
Streptococcus pneumoniae
  Synonym
Micrococcus pneumoniae
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Respiratory or Fermentative
  Gram
Positive
  Host Relationship
Pathogen
  Genome Size (bp)
2188259
  No. of Base Pairs
2188259
  Description
Streptococcus pneumoniae, or pneumococcus, is a facultative anaerobic, gram-positive, alpha-hemolytic or beta-hemolytic member of the genus Streptococcus. They are usually found in pairs and do not form spores and are nonmotile. As a significant human pathogenic bacteria S. pneumoniae was recognized as a major cause of pneumonia.
  External Links Taxonomy ID 1313
GutMDisorder ID gm0624
Genome Assembly ID ASM576862v2
GOLD Database ID Go0003791
GIMICA ID MIC01263

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: Hydrogen peroxide (H2O2) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info BEAS-2B cells lysine 8 . [1], [2]
Histone Dephosphorylation H3 EM Info A549 cells serine 10 . [1]
Histone Methylation H3 EM Info BEAS-2B cells lysine 27 . [1], [2]
Histone Methylation H3 EM Info BEAS-2B cells lysine 4 . [1], [2]
Histone Methylation H3 EM Info BEAS-2B cells lysine 9 . [1], [2]

Full List of Protein(s) Produced by This MIC
     Protein Type: .
           Protein Name: Pneumolysin Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info HeLa cells serine 10 Streptococcus pneumoniae [3]
     Protein Type: Microbial secreted proteins
           Protein Name: Pyruvate oxidase SpxB Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info A549 cells serine10 . [1]

References
1 Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase. Cell Rep. 2020 Mar 24;30(12):4016-4026.e4. doi: 10.1016/j.celrep.2020.02.116.
2 Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med. 2015 May;82:22-8. doi: 10.1016/j.freeradbiomed.2015.01.028. Epub 2015 Feb 3.
3 Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. doi: 10.1073/pnas.0702729104. Epub 2007 Aug 3.

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