| General Information of MIC (ID: MC1054) |
| MIC Name |
Clostridium leptum
|
| Lineage |
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
|
| Oxygen Sensitivity |
Anaerobe
|
| Microbial Metabolism |
Saccharolytic; Fermentative; Reduction
|
| Gram |
Positive
|
| Host Relationship |
Commensal
|
| Genome Size (bp) |
3270109
|
| Description |
Clostridium leptum is a bacteria species in the genus Clostridium. It forms a subgroup of human fecal microbiota. Its reduction relative to other members of the gut microbiota has been observed in patients with inflammatory bowel disease.
|
| External Links |
Taxonomy ID |
1535
|
| GutMDisorder ID |
gm0204
|
| GOLD Database ID |
Go0002246
|
| GIMICA ID |
MIC00402
|
| Full List of Metabolite(s) Produced by This MIC |
| Molecule Type: Fatty acids |
|---|
| Metabolite Name: Butyrate |
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|
| Detailed Infomation |
Meta Info
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|
Metabolic Classification |
Microbial producted compound [end-products] |
| Modification Type |
Molecule |
EM Info |
Cell/Tissue Type |
Modified sites |
Condition |
REF |
| Histone Acetylation |
H3 |
EM Info
|
CD41T cells |
Foxo3A promoter |
. |
[1], [2] |
| miRNA |
miR-92a |
EM Info
|
Colon cancer cells |
. |
Colon cancer |
[3], [1] |
| References |
| 1 |
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice. Clin Epigenetics. 2012 Feb 27;4(1):4. doi: 10.1186/1868-7083-4-4.
|
| 2 |
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
|
| 3 |
Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
|
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