Details of Microbe Species (MIC)

General Information of MIC (ID: MC1027)
  MIC Name
Fusobacterium varium
  Synonym
Bacteroides varius
  Lineage Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative; Proteolytic
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
3321664
  No. of Coding Genes
2734
  No. of Non-Coding Genes
86
  No. of Small Non-Coding Genes
86
  No. of Gene Transcripts
2820
  Description
Fusobacteria varium is a genus of anaerobic, gram-negative, non-sporeforming bacteria, similar to Bacteroides.
  External Links Taxonomy ID 856
GutMDisorder ID gm0344
Genome Assembly ID ASM69626v1
GOLD Database ID Go0003599
GIMICA ID MIC00621

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Polyamines
           Metabolite Name: Spermine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3B EM Info Jurkat cells . . [1], [2]
DNA Methylation DNMT3A EM Info Jurkat cells . . [1], [2]
Histone Acetylation H3 EM Info HT1080 cells . . [1], [3]
Histone Acetylation HAT1 EM Info HT1080 cells . . [1], [3]
Histone Deacetylation HDAC1 EM Info HT1080 cells . . [1], [3]
Histone Deacetylation SIRT1 EM Info HT1080 cells . . [1], [3]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Extracellular Spermine Activates DNA Methyltransferase 3A and 3B. Int J Mol Sci. 2019 Mar 12;20(5):1254. doi: 10.3390/ijms20051254.
3 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.

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