Details of Microbe Species (MIC)

General Information of MIC (ID: MC0993)
  MIC Name
Flavonifractor plautii
  Synonym
Bacillus plauti, Clostridium orbiscindens, Eubacterium plautii, Fusobacterium plautii, Fusocillus plauti, Zuberella plauti
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
Genus: Flavonifractor
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Description
Flavonifractor plautii (formerly Eubacteria plautii) is an anaerobic gram positive rod shaped bacteria belonging to the family of Clostridiales, and a common member of the human gut microbiome.
  External Links Taxonomy ID 292800
GutMDisorder ID gm0339
GIMICA ID MIC01414

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [1], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [3], [4]
     Molecule Type: Phenylpropanoids and polyketides
           Metabolite Name: 3-(4-hydroxyphenyl)propionic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info HT-29 cells . Colorectal cancer [3], [4]


References
1 Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem. 2008 Sep;19(9):587-93. doi: 10.1016/j.jnutbio.2007.08.002. Epub 2007 Dec 3.
2 Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes. 2016 May 3;7(3):216-34. doi: 10.1080/19490976.2016.1158395. Epub 2016 Mar 10.
3 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
4 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation BMC Microbiol. 2019 May 16;19(1):99. doi: 10.1186/s12866-019-1483-x.

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