| General Information of Metabolite (ID: MT103) |
| Meta Name |
3-(4-hydroxyphenyl)propionic acid
|
| Unify Name |
Desaminotyrosine
|
| Synonym |
Click to Show/Hide the Detailed Synonyms of This Metabolite
3-(4-Hydroxyphenyl)propionic acid;3-(p-Hydroxyphenyl)propionic acid;4-Hydroxyphenylpropionic acid;beta-(p-Hydroxyphenyl)propionic acid;Dihydro-p-coumaric acid;HYDROXYPHENYL propionIC ACID;p-Hydroxyhydrocinnamic acid;p-Hydroxyphenylpropionic acid;Phloretinic acid;Phloretic acid;3-(4-Hydroxyphenyl)propionate;3-(p-Hydroxyphenyl)propionate;4-Hydroxyphenylpropionate;b-(p-Hydroxyphenyl)propionate;b-(p-Hydroxyphenyl)propionic acid;beta-(p-Hydroxyphenyl)propionate;beta-(p-hydroxyphenyl)propionate;beta-(p-hydroxyphenyl)propionic acid;Dihydro-p-coumarate;HYDROXYPHENYL propionate;p-Hydroxyhydrocinnamate;p-Hydroxyphenylpropionate;Phloretinate;Phloretate;3-(4'-Hydroxyphenyl)-propionate;3-(4'-Hydroxyphenyl)-propionic acid;3-(4'-Hydroxyphenyl)propionic acid;3-(4-Hydroxy-phenyl)-propionate;3-(4-Hydroxy-phenyl)-propionic acid;3-(4-Hydroxyphenyl)-propionate;3-(4-Hydroxyphenyl)-propionic acid;3-(4-Hydroxyphenyl)propanoate;3-(4-Hydroxyphenyl)propanoic acid;3-(Para-hydroxyphenyl)propionate;3-(Para-hydroxyphenyl)propionic acid;4'-Hydroxyphenylpropionic acid;4-(4-Hydroxyphenylpropanoate;4-(4-Hydroxyphenylpropanoic acid;4-Hydroxy-(9ci)benzenepropanoate;4-Hydroxy-(9ci)benzenepropanoic acid;4-Hydroxy-benzenepropanoate;4-Hydroxy-benzenepropanoic acid;4-Hydroxybenzenepropanoate;4-Hydroxybenzenepropanoic acid;Hydro-p-coumarate;Hydro-p-coumaric acid;Hydroxy-hydrocinnamic acid;N-Hydroxysuccinimide ester;p-Hydroxy-benzene propionate;p-Hydroxy-benzene propionic acid;p-Hydroxy-hydrocinnamate;p-Hydroxy-hydrocinnamic acid;4-Hydroxyhydrocinnamic acid;Desaminotyrosine
|
| Molecule Type |
Phenylpropanoids and polyketides
|
| Formula |
C9H9O3
|
| Inchi Key |
NMHMNPHRMNGLLB-UHFFFAOYSA-N
|
| Description |
Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Desaminotyrosine is a normal constituent of human urine. A product of tyrosine metabolism; concentration in urine increases in patients with gastrointestinal diseases. (Dictionary of Organic Compounds). It is considered also that may result from metabolism to phenolic acids by colonic bacteria.
|
| External Links |
HMDB ID |
HMDB0002199
|
| VMH ID |
phppa
|
| KEGG ID |
C01744
|
| Metlin ID |
4148
|
| The epigenetic modification information of this metabolite |
| Modification Type |
Molecule |
EM Info |
Cell/Tissue Type |
Modified sites |
Condition |
REF |
| Histone Deacetylation |
HDAC |
EM Info
|
HT-29 cells |
. |
Colorectal cancer |
[1], [2] |
| The microbes that produce this metabolite |
| Flavonifractor plautii |
| Detailed Information |
MIC Info
 click to show the detail information of this Microbiota
|
[3], [4] |
| Description |
Flavonifractor plautii (formerly Eubacteria plautii) is an anaerobic gram positive rod shaped bacteria belonging to the family of Clostridiales, and a common member of the human gut microbiome.
|
| Eubacterium ramulus DSM 16296 |
| Detailed Information |
MIC Info
click to show the detail information of this Microbiota
|
[1], [2] |
| Description |
Eubacterium ramulus DSM 16296 is an anaerobe, mesophilic bacterium that was isolated from human feces.
|
| References |
| 1 |
Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem. 2008 Sep;19(9):587-93. doi: 10.1016/j.jnutbio.2007.08.002. Epub 2007 Dec 3.
|
| 2 |
Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes. 2016 May 3;7(3):216-34. doi: 10.1080/19490976.2016.1158395. Epub 2016 Mar 10.
|
| 3 |
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
|
| 4 |
Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation BMC Microbiol. 2019 May 16;19(1):99. doi: 10.1186/s12866-019-1483-x.
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