Details of Microbe Species (MIC)

General Information of MIC (ID: MC0971)
  MIC Name
Peptostreptococcus anaerobius
  Synonym
Streptococcus anaerobius
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptostreptococcaceae
Genus: Peptostreptococcus
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative; Phenylalanine metabolism; Leucine metabolism
  Gram
Positive
  Genome Size (bp)
1988071
  No. of Coding Genes
1936
  No. of Non-Coding Genes
11
  No. of Small Non-Coding Genes
11
  No. of Gene Transcripts
1947
  No. of Base Pairs
2019341
  Description
Peptostreptococcus anaerobius is a gram-positive anaerobic coccus that is widely distributed in the normal human flora. The organism has also been implicated as a causative agent of several systemic infections, including endocarditis and infections of the genitourinary and gastrointestinal tracts.
  External Links Taxonomy ID 1261
GutMDisorder ID gm0521
Genome Assembly ID ASM156359v1
GOLD Database ID Go0003934
GIMICA ID MIC00980

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Valerate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info . . . [3], [4]
Histone Acetylation H4 EM Info . . . [3], [4]
Histone Deacetylation HDAC2 EM Info HT-29 cells . . [5], [4]
Histone Deacetylation HDAC2 EM Info HT-29 cells . Health [5], [4]
Histone Deacetylation HDAC1 EM Info HT-29 cells . . [5], [4]
Histone Deacetylation HDAC3 EM Info HT-29 cells . . [5], [4]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Use of modified norleucine-tyrosine broth in identification of Peptostreptococcus anaerobius J Clin Microbiol. 1990 Sep;28(9):2120-1. doi: 10.1128/jcm.28.9.2120-2121.1990.
5 Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.

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