Details of Microbe Species (MIC)

General Information of MIC (ID: MC0846)
  MIC Name
Clostridium scindens
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Lachnoclostridium
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Genome Size (bp)
3619905
  Description
Clostridium scindens is a species of bacteria in the genus Clostridium. Samples of this species were first isolated from human feces. Clostridia are anaerobic, motile bacteria, ubiquitous in nature, and especially prevalent in soil.
  External Links Taxonomy ID 29347
Genome Assembly ID ASM15450v1
GOLD Database ID Go0000897
GIMICA ID MIC00416

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Bile acids (BAs)
           Metabolite Name: Deoxycholic acid (DCA) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation FXR/NR1H4 EM Info White blood peripheral cells promoter Intrahepatic cholestasis of pregnancy [1], [2]
DNA Methylation FXR EM Info HCT-116 cells promoter Colon cancer [2], [3]


References
1 Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype. PLoS One. 2014 Jan 31;9(1):e87697. doi: 10.1371/journal.pone.0087697. eCollection 2014.
2 A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer Am J Clin Nutr. 2020 Feb 1;111(2):406-419. doi: 10.1093/ajcn/nqz301.
3 Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. J Nutr. 2016 Feb;146(2):236-42. doi: 10.3945/jn.115.216580. Epub 2015 Nov 25.

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