Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10051)
  Official Symbol
NR1H4
  Official Full Name
nuclear receptor subfamily 1 group H member 4
  Synonym
FXR;HRR-1;HRR1;RIP14
  Molecule Type
Protein coding
  Position On Chromosome
chr12(Start:100473708 - End:100564414)
  Strand
+
  Uniprot Entry
F1DAL1 
  ENSG ID
ENSG00000012504 
  Dnmivd Disease
KIRC 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Deoxycholic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Deoxycholic acid couldinduce FXR expression and lower CpG methylation of FXR in human HCT-116 colon cancer cells.

References
1 A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer Am J Clin Nutr. 2020 Feb 1;111(2):406-419. doi: 10.1093/ajcn/nqz301.
2 Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. J Nutr. 2016 Feb;146(2):236-42. doi: 10.3945/jn.115.216580. Epub 2015 Nov 25.

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