Details of Microbe Species (MIC)

General Information of MIC (ID: MC0109)
  MIC Name
Eggerthella lenta
  Synonym
Bacteroides lentus
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Genome Size (bp)
3632260
  Description
Eggerthella lenta is a species of aerobic, gram-negative, rod shaped bacteria in the phylum Actinobacteria. E. lenta is a commensal organism of the gastrointestinal tract and is rarely associated with infections.
  External Links Taxonomy ID 84112
GutMDisorder ID gm0271
Genome Assembly ID ASM2426v1
GOLD Database ID Go0001217
GIMICA ID MIC00520

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
           Metabolite Name: Phenylbutyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info D283-MED cells . . [1], [2]
Histone Acetylation H3 EM Info DAOY cells . . [1], [2]
Histone Acetylation H4 EM Info D283-MED cells . . [1], [2]
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [3], [4]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [5], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [5], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [4], [6]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [4], [6]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [4], [6]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [3], [4]


References
1 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
2 Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243(T) Gut Microbes. 2018 Nov 2;9(6):523-539. doi: 10.1080/19490976.2018.1458180. Epub 2018 May 24.
3 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
4 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
5 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
6 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.

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