Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10071)
Official Symbol		HDM
Official Full Name		histone demethylase

Metabolite(s) with this epigenetic modification
Metabolite Name: Spermine
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Spermine has been shown to inhibit histone demethylase.
Metabolite Name: Cadaverine
Detailed Information	Meta Info click to show the detail information of this Metabolite	[3], [4]
Description	Cadaverine has been shown to inhibit histone demethylase..

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4.
3	Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4	Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.

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