Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12429)
  Official Symbol
TAL1
  Official Full Name
TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor
  Synonym
BHLHa17;TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor;SCL;TCL5;T-Cell Acute Lymphocytic Leukemia Protein 1;Class A Basic Helix-Loop-Helix Protein 17;Tal-1 Product;BHLHA17;Tal-1;TAL-1
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:47216290 - End:47232389)
  Strand
-
  Uniprot Entry
P17542 
  ENSG ID
ENSG00000162367 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TAL1 gene hypermethylation in THP-1 cells.
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
S-Adenosylmethionine was proved to be decrease TAL1 methylation in SW480 cells.
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
S-Adenosylmethionine was proved to be decrease TAL1 methylation in SW480 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74. doi: 10.1186/s13148-017-0374-y. eCollection 2017.
4 S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression. Cells. 2020 Aug 9;9(8):1864. doi: 10.3390/cells9081864.
5 Progress in the microbial production of S-adenosyl-L-methionine World J Microbiol Biotechnol. 2016 Sep;32(9):153. doi: 10.1007/s11274-016-2102-8. Epub 2016 Jul 27.

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