Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM01876)
  Official Symbol
MLH1
  Official Full Name
mutL homolog 1
  Synonym
COCA2;FCC2;HNPCC;HNPCC2
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:36993332 - End:37050918)
  Strand
+
  Uniprot Entry
P40692 
  ENSG ID
ENSG00000076242 
  Dnmivd Disease
KIRC 
    Disease Relevance (Click to Show/Hide)
         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C73: Malignant neoplasms of ovary Ovarian carcinoma (OVCA) [Malignant neoplasms of ovary]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A20: Acquired immunodeficiencies Immunodeficiency [Acquired immunodeficiencies]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         5B81: Obesity Obesity [Obesity]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6C40: Disorders due to use of alcohol Alcohol use disorder (AUD) [Disorders due to use of alcohol]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8E49: Postviral fatigue syndrome Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [Postviral fatigue syndrome]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LD2F: Syndromes with multiple structural anomalies, without predominant body system involvement Silver russell syndrome [Syndromes with multiple structural anomalies, without predominant body system involvement]
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         LD44: Deletions of the autosomes Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         XB8M: Congenital Melanoma [Congenital]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1ND9: Papillary carcinoma of thyroid Papillary thyroid carcinoma [Papillary carcinoma of thyroid]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
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         XH94U0: Pituitary adenoma Nonfunctioning pituitary adenomas [Pituitary adenoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN3DY: Helicobacter pylori Helicobacter pylori infection [Helicobacter pylori]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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         ZERO(Not Found): Constitutional MLH1 epimutations Constitutional MLH1 epimutations [Constitutional MLH1 epimutations]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce MLH1 gene hypermethylation in THP-1 cells.
  Metabolite Name: Folate (B9)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Folate (B9) correlated with DNA methylation in specific CpG sites of MLH1.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate MLH1 CpG site in breast cancer cells.
  Metabolite Name: Pyridoxine (B6)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Pyridoxine (B6) could be induce hypermethylation of the mismatch repair gene MutL homolog 1 (MLH1).

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [5]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host MLH1 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
4 Human Breast Milk Promotes the Secretion of Potentially Beneficial Metabolites by Probiotic Lactobacillus reuteri DSM 17938 Nutrients. 2019 Jul 9;11(7):1548. doi: 10.3390/nu11071548.
5 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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