Target Information

Target General Infomation
Target ID
T77236
Former ID
TTDR01032
Target Name
Cathepsin F
Gene Name
CTSF
Synonyms
CATSF; CTSF
Target Type
Research
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
BioChemical Class
Peptidase
Target Validation
T77236
UniProt ID
Q9UBX1
EC Number
EC 3.4.22.41
Sequence
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRA
VLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLL
RKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLP
VKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLT
EEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQ
GHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL
RPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASS
AVVD
Inhibitor Benzoyl-Arginine-Alanine-Methyl Ketone Drug Info [551393]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE Drug Info [551374]
compound (R)-26 Drug Info [531940]
HOMOPHENYLALANINYLMETHANE Drug Info [551374]
WRR-112 Drug Info [551393]
WRR-99 Drug Info [551393]
Pathways
KEGG Pathway Lysosome
NetPath Pathway IL2 Signaling Pathway
Reactome MHC class II antigen presentation
References
Ref 531940Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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