Drug Information

Drug General Information
Drug ID
D06WQP
Former ID
DIB019161
Drug Name
compound (R)-26
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531940], [541663]
Formula
C17H24N4O4S
InChI
InChI=1S/C17H24N4O4S/c1-13(2)10-26(24,25)11-15(17(23)21(4)20(3)12-18)19-16(22)14-8-6-5-7-9-14/h5-9,13,15H,10-11H2,1-4H3,(H,19,22)/t15-/m0/s1
InChIKey
UGAZRSHSXNNYTK-HNNXBMFYSA-N
PubChem Compound ID
60148519
PubChem Substance ID
144076506, 163316704, 163341239, 178103149
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [531940]
Cathepsin F Target Info Inhibitor [531940]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosishsa04142:Lysosome
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-2132295:MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 531940Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
Ref 541663(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6535).
Ref 531940Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.

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