Target Information

Target General Infomation
Target ID
T42822
Former ID
TTDS00437
Target Name
Ferrochelatase
Gene Name
FECH
Synonyms
Heme synthetase; Protoheme ferro-lyase; FECH
Target Type
Successful
Disease Acne vulgaris [ICD9: 706.1; ICD10: L70.0]
Function
Catalyzes the ferrous insertion into protoporphyrin IX.
BioChemical Class
Ferrochelatase
UniProt ID
P22830
EC Number
EC 4.99.1.1
Sequence
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Drugs and Mode of Action
Drug(s) Cholic Acid Drug Info Approved Peroxisomal disorders; Synthesis disorders [541327]
Methyl aminolevulinate Drug Info Approved Acne vulgaris [538565], [551871]
Inhibitor Cholic Acid Drug Info [551393]
Lead acetate Drug Info [534912]
N-Methylmesoporphyrin Drug Info [551393]
N-Methylmesoporphyrin Containing Copper Drug Info [551393]
Activator Methyl aminolevulinate Drug Info [537341]
Pathways
BioCyc Pathway Heme biosynthesis
Heme biosynthesis from uroporphyrinogen-III I
KEGG Pathway Porphyrin and chlorophyll metabolism
Metabolic pathways
PANTHER Pathway Heme biosynthesis
Pathway Interaction Database HIF-1-alpha transcription factor network
PathWhiz Pathway Porphyrin Metabolism
WikiPathways Heme Biosynthesis
Metabolism of porphyrins
References
Ref 538565FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021415.
Ref 541327(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 609).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534912Ferrochelatase, a novel target for photodynamic therapy of cancer. Oncol Rep. 1999 Nov-Dec;6(6):1439-42.
Ref 537341Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. Epub 2009 May 15.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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