Drug Information

Drug General Information
Drug ID
D0OL6O
Former ID
DAP001024
Drug Name
Methyl aminolevulinate
Synonyms
Metvix; Aminolevulinic acid methyl ester; Methyl 5-aminolevulinate; Methyl delta-aminolevulinate; Methyl5-amino-4-oxopentanoate; Levulinic acid, 5-amino-, methyl ester; Pentanoic acid, 5-amino-4-oxo-, methyl ester; 5-Aminolevulinic acid methyl ester
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Approved [538565], [551871]
Therapeutic Class
Anticancer Agents
Formula
C6H11NO3
Canonical SMILES
COC(=O)CCC(=O)CN
InChI
1S/C6H11NO3/c1-10-6(9)3-2-5(8)4-7/h2-4,7H2,1H3
InChIKey
YUUAYBAIHCDHHD-UHFFFAOYSA-N
CAS Number
CAS 33320-16-0
PubChem Compound ID
157922
PubChem Substance ID
3152707, 6729582, 10253237, 14747821, 46233440, 46507004, 50070563, 50071305, 50100968, 75370426, 96024892, 99333768, 103749693, 104171381, 113438636, 124883561, 124883562, 125824630, 126570614, 129851228, 132503116, 134221978, 134224946, 134338292, 135141172, 137127158, 142505868, 160964329, 165372994, 175268075, 179151184, 203088301, 223541399, 223817042, 225144187, 226399702
SuperDrug ATC ID
L01XD03
SuperDrug CAS ID
cas=079416276
Target and Pathway
Target(s) Ferrochelatase Target Info Activator [537341]
BioCyc Pathway Heme biosynthesis
Heme biosynthesis from uroporphyrinogen-III I
KEGG Pathway Porphyrin and chlorophyll metabolism
Metabolic pathways
PANTHER Pathway Heme biosynthesis
Pathway Interaction Database HIF-1-alpha transcription factor network
PathWhiz Pathway Porphyrin Metabolism
WikiPathways Heme Biosynthesis
Metabolism of porphyrins
References
Ref 538565FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021415.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537341Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. Epub 2009 May 15.

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