Target Information

Target General Infomation
Target ID
T15514
Former ID
TTDR00269
Target Name
Hepatocyte nuclear factor 4-alpha
Gene Name
HNF4A
Synonyms
HNF-4-alpha; Transcription factor 14; Transcription factor HNF-4; HNF4A
Target Type
Research
Function
Transcriptionally controlled transcription factor. Binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. May be essential for development of the liver, kidney and intestine.
BioChemical Class
Nuclear hormone receptor
UniProt ID
P41235
Sequence
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Antagonist BI6015 Drug Info [531980]
Inhibitor Lauric Acid Drug Info [551393]
MYRISTIC ACID Drug Info [551374]
Pathways
KEGG Pathway AMPK signaling pathway
Maturity onset diabetes of the young
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Reactome Nuclear Receptor transcription pathway
WikiPathways Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
AMPK Signaling
References
Ref 531980HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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