Drug Information

Drug General Information
Drug ID
D02RRY
Former ID
DIB018969
Drug Name
BI6015
Synonyms
BI 6015; BI-6015
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541800]
Formula
C15H13N3O4S
InChI
InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
InChIKey
ILVCPQPMRPHZSG-UHFFFAOYSA-N
PubChem Compound ID
3269393
PubChem Substance ID
4305501, 9250917, 34643400, 48294592, 72035629, 76807887, 93321380, 106832750, 111873415, 118687072, 143901364, 164058091, 166708326, 170474672, 178103306, 196373099, 229483309, 246108201, 252158239, 252160588
Target and Pathway
Target(s) Hepatocyte nuclear factor 4-alpha Target Info Antagonist [531980]
KEGG Pathway AMPK signaling pathway
Maturity onset diabetes of the young
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Reactome Nuclear Receptor transcription pathway
WikiPathways Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
AMPK Signaling
References
Ref 541800(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6695).
Ref 531980HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18.

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