Drug Information

Drug General Information
Drug ID
D0AK9X
Former ID
DNC014693
Drug Name
4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528071]
Formula
C8H10ClNO2S
Canonical SMILES
C1=C(SC(=C1)Cl)C(CC(=O)O)CN
InChI
1S/C8H10ClNO2S/c9-7-2-1-6(13-7)5(4-10)3-8(11)12/h1-2,5H,3-4,10H2,(H,11,12)
InChIKey
CDFQDLUHBLZCGL-UHFFFAOYSA-N
PubChem Compound ID
125917
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Inhibitor [528071]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 528071J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.
Ref 528071J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.

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