Drug Information

Drug General Information
Drug ID
D0X9YS
Former ID
DIB018888
Drug Name
AS-19
Synonyms
AS 19; AS19
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529256]
Formula
C18H25N3
InChI
InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1
InChIKey
BTTOYOKCLDAHHO-HNNXBMFYSA-N
PubChem Compound ID
23642275
PubChem Substance ID
46502276, 103918438, 137006646, 162220293, 163334533, 226619003, 241375716, 243382257, 249617456, 252156224, 252166643
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Agonist [532288]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 529256The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195(1):112-9.
Ref 532288Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorg Med Chem. 2013 May 1;21(9):2568-76.

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