Drug Information

Drug General Information
Drug ID
D0X8MI
Former ID
DIB010051
Drug Name
Berupipam
Synonyms
NNC-22-0010
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 1 [545634]
Company
Novo Nordisk A/S
Formula
C19H19BrClNO2
Canonical SMILES
c1([C@@H]2c3c(cc(c(c3)O)Cl)CCN(C2)C)c2c(cc(c1)Br)CCO2
CAS Number
CAS 150490-85-0
PubChem Compound ID
66002
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Antagonist [533594]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 545634Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004006)
Ref 533594Characterization of benzazepine UDP-glucuronosyl-transferases in laboratory animals and man. Xenobiotica. 1995 Jun;25(6):611-22.

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