Drug Information

Drug General Information
Drug ID
D0M7SY
Former ID
DIB020912
Drug Name
SB269652
Synonyms
SB-269652; SB-269,652
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532129]
Formula
C27H30N4O
InChI
InChI=1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-
InChIKey
JGLGOAQPUQITLD-OGAOHHHESA-N
PubChem Compound ID
9910352
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator (allosteric modulator) [532915]
D(3) dopamine receptor Target Info Modulator (allosteric modulator) [533107]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 532129Bridging the gap: bitopic ligands of G-protein-coupled receptors. Trends Pharmacol Sci. 2013 Jan;34(1):59-66.
Ref 532915A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52.
Ref 533107Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. Eur Neuropsychopharmacol. 2015 Sep;25(9):1448-61.

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