Drug Information

Drug General Information
Drug ID
D0L7RB
Former ID
DNC006145
Drug Name
1-(4-hydroxyphenyl)prop-2-en-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527869]
Formula
C9H8O2
Canonical SMILES
C=CC(=O)C1=CC=C(C=C1)O
InChI
1S/C9H8O2/c1-2-9(11)7-3-5-8(10)6-4-7/h2-6,10H,1H2
InChIKey
NKPPNPJUBLEKAD-UHFFFAOYSA-N
PubChem Compound ID
16036927
Target and Pathway
Target(s) 4-aminobutyrate aminotransferase, mitochondrial Target Info Inhibitor [527869]
Succinate semialdehyde dehydrogenase, mitochondrial Target Info Inhibitor [527869]
BioCyc Pathway GABA shunt
Valine degradation
Beta-alanine degradation
4-aminobutyrate degradationGLUDEG-I-PWY:GABA shunt
4-aminobutyrate degradation
KEGG Pathway Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Metabolic pathways
GABAergic synapsehsa00250:Alanine, aspartate and glutamate metabolism
PANTHER Pathway Aminobutyrate degradation
Pyrimidine Metabolism
Gamma-aminobutyric acid synthesisP02726:Aminobutyrate degradation
Gamma-aminobutyric acid synthesis
PathWhiz Pathway Aspartate Metabolism
Glutamate Metabolism
Beta-Alanine Metabolism
Valine, Leucine and Isoleucine Degradation
Propanoate MetabolismPW000003:Glutamate Metabolism
WikiPathways GABA synthesis, release, reuptake and degradation
Alanine and aspartate metabolismWP2685:GABA synthesis, release, reuptake and degradation
References
Ref 527869Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
Ref 527869Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.

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