Drug Information

Drug General Information
Drug ID
D0H2IA
Former ID
DIB019112
Drug Name
CGP 56999A
Synonyms
CGP56999A; CGP-56999A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538654]
Formula
C19H30NO5P
InChI
InChI=1S/C19H30NO5P/c1-14(16-8-5-9-17(10-16)19(22)23)20-11-18(21)13-26(24,25)12-15-6-3-2-4-7-15/h5,8-10,14-15,18,20-21H,2-4,6-7,11-13H2,1H3,(H,22,23)(H,24,25)/t14-,18+/m1/s1
InChIKey
JCFULPDIJOVUHP-KDOFPFPSSA-N
PubChem Compound ID
9800175
PubChem Substance ID
14756046, 14829515, 24109279, 44836180, 75206730, 134224206, 135650075, 229018709
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [534343]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538654(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1071).
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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