Drug Information

Drug General Information
Drug ID
D09ULA
Former ID
DIB020621
Drug Name
OPC 4392
Synonyms
OPC-4392
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539746]
Formula
C24H29N3O2
InChI
InChI=1S/C24H29N3O2/c1-18-5-3-6-23(19(18)2)27-14-12-26(13-15-27)11-4-16-29-21-9-7-20-8-10-24(28)25-22(20)17-21/h3,5-10,17H,4,11-16H2,1-2H3,(H,25,28)
InChIKey
RRLWEQBPSAFVAS-UHFFFAOYSA-N
PubChem Compound ID
163839
PubChem Substance ID
10255265, 12013865, 14927742, 46238169, 47434829, 48253934, 50880119, 57350218, 85209962, 103242890, 103807282, 113452591, 117622124, 125738472, 129171231, 131342639, 135119216, 135650775, 162311074, 162775484, 179293923, 228537121
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Agonist [525492]
5-hydroxytryptamine 7 receptor Target Info Agonist [525492]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04014:Ras signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, Other
References
Ref 539746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 268).
Ref 525492Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27.

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