Drug Information

Drug General Information
Drug ID
D09QRL
Former ID
DNC012238
Drug Name
2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533578]
Formula
C16H17N
Canonical SMILES
CN1CCC2=CC=CC(=C2C1)C3=CC=CC=C3
InChI
1S/C16H17N/c1-17-11-10-14-8-5-9-15(16(14)12-17)13-6-3-2-4-7-13/h2-9H,10-12H2,1H3
InChIKey
XBKQADUXVZAYDY-UHFFFAOYSA-N
PubChem Compound ID
3057770
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [533578]
D(2) dopamine receptor Target Info Inhibitor [533578]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 533578J Med Chem. 1981 Sep;24(9):1107-10.Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.
Ref 533578J Med Chem. 1981 Sep;24(9):1107-10.Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.

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