Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PWX
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| Former ID |
DNC004667
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| Drug Name |
Carzenide
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| Synonyms |
Para-Carboxybenzenesulfonamide (Weak Carbonic Anhydrase Inhibitor)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [529948] | ||
| Formula |
C7H7NO4S
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| Canonical SMILES |
C1=CC(=CC=C1C(=O)O)S(=O)(=O)N
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| InChI |
1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
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| InChIKey |
UCAGLBKTLXCODC-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase XIV | Target Info | Inhibitor | [527654] | |
| Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase XII | Target Info | Inhibitor | [527407] | ||
| Carbonic anhydrase II | Target Info | Inhibitor | [527786] | ||
| Carbonic anhydrase | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase I | Target Info | Inhibitor | [530046] | ||
| KEGG Pathway | Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism | ||||
| Proximal tubule bicarbonate reclamation | |||||
| Collecting duct acid secretion | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Bile secretionhsa00910:Nitrogen metabolism | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | ||||
| Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway | ||||
| Reversible Hydration of Carbon Dioxide | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in leukocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| References | |||||
| Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
| Ref 527654 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. | ||||
| Ref 527786 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. Epub 2005 Oct 6.Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. | ||||
| Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
| Ref 530046 | Nat Chem Biol. 2009 May;5(5):341-3. Epub 2009 Mar 29.Ligand-directed tosyl chemistry for protein labeling in vivo. | ||||
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