Drug Information

Drug General Information
Drug ID
D09GBZ
Former ID
DIB018412
Drug Name
[3H]SCH-23390
Synonyms
[3H]-SCH23390
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543317]
Formula
C17H18ClNO
InChI
InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
InChIKey
GOTMKOSCLKVOGG-UHFFFAOYSA-N
PubChem Compound ID
5018
PubChem Substance ID
5198913, 8153088, 14824725, 29224090, 47359444, 47656604, 49877975, 53787346, 57322568, 79039249, 81065503, 85209295, 103808687, 104234153, 104308043, 117460133, 127984472, 134340354, 134340511, 135651025, 135651204, 136352280, 137010143, 142334897, 142773268, 162169313, 162223703, 162311109, 163292175, 179236089, 231517379
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Antagonist [531521]
D(1B) dopamine receptor Target Info Antagonist [533868]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04020:Calcium signaling pathway
PANTHER Pathway Dopamine receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 543317(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 946).
Ref 531521Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 6;347(6288):76-80.
Ref 533868Dopamine D5 receptors in human peripheral blood lymphocytes: a radioligand binding study. J Neuroimmunol. 1994 Aug;53(1):1-7.

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