Drug Information

Drug General Information
Drug ID
D06VDN
Former ID
DNC001289
Drug Name
SB 243213
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539239]
Formula
C22H19F3N4O2
InChI
InChI=1S/C22H19F3N4O2/c1-13-10-15-7-9-29(18(15)11-17(13)22(23,24)25)21(30)28-16-5-6-20(27-12-16)31-19-4-3-8-26-14(19)2/h3-6,8,10-12H,7,9H2,1-2H3,(H,28,30)
InChIKey
ZETBBVYSBABLHL-UHFFFAOYSA-N
CAS Number
CAS 200940-22-3
PubChem Compound ID
443391
PubChem Substance ID
13908, 6613379, 10299305, 14929825, 36886718, 52271941, 57404369, 85209681, 103176823, 103985471, 104629873, 124954243, 129892102, 134222839, 134339145, 134340495, 134346773, 135650999, 135723606, 137926215, 196376764, 223440905, 226972632, 252214546
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [535230]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539239(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 194).
Ref 535230SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology. 2001 Aug;41(2):186-99.

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