Drug Information

Drug General Information
Drug ID
D06RRD
Former ID
DNC000646
Drug Name
Fibrates
Drug Type
Small molecular drug
Indication Dyslipidaemias [ICD9: 272; ICD10:E78] Investigative [536740]
Formula
C10H11ClO3
Canonical SMILES
CC(C)(C(=O)O)OC1=CC=C(C=C1)Cl
InChI
1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)
InChIKey
TXCGAZHTZHNUAI-UHFFFAOYSA-N
PubChem Compound ID
2797
PubChem Substance ID
67999, 586289, 3138061, 4302949, 8149263, 8151806, 10321140, 10537404, 11112452, 11113721, 11335401, 11360640, 11363054, 11365616, 11368178, 11371371, 11373985, 11376340, 11461612, 11466811, 11467931, 11484030, 11486561, 11487973, 11490172, 11492108, 11493974, 15390199, 24851846, 26528140, 26611666, 26679577, 26747130, 26747131, 26751907, 26751908, 29199188, 29221952, 47291022, 47588878, 47662148, 47736353, 47885292, 47959611, 48034989, 48259105, 48438735, 49698691, 49836655, 50025535
Target and Pathway
Target(s) Peroxisome proliferator activated receptor alpha Target Info Agonist [536740]
KEGG Pathway PPAR signaling pathway
cAMP signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Circadian Clock
Nuclear Receptors
References
Ref 536740Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
Ref 536740Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.

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