Drug Information

Drug General Information
Drug ID
D05GKD
Former ID
DAP000140
Drug Name
Tramadol
Synonyms
Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram; Ultram
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [537244], [543040]
Therapeutic Class
Analgesics
Company
Chemie Grunenthal of Stolberg-am-Rhein
Formula
C16H25NO2
InChIKey
TVYLLZQTGLZFBW-UHFFFAOYSA-N
CAS Number
CAS 27203-92-5
PubChem Compound ID
5523
PubChem Substance ID
5658598, 8153398, 15221636, 29224565, 49958171, 49958172, 49958173, 50837838, 85209685, 103113054, 104309473, 117617520, 123083206, 125679912, 126682485, 129321889, 134995846, 135060961, 137010486, 142192184, 162831124, 164174929, 164765703, 164765706, 179225203, 184526607, 184596120, 216106831, 223656715, 223766038, 226439878, 241058775, 244533735, 249923528, 252166498
SuperDrug ATC ID
N02AX02
SuperDrug CAS ID
cas=027203925
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Modulator [527050]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 537244Local effect of tramadol on formalin evoked flinching behavior in rats. Rev Bras Anestesiol. 2008 Jul-Aug;58(4):375-9, 371-5.
Ref 543040(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8286).
Ref 527050The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents.

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