Drug Information

Drug General Information
Drug ID
D03DXS
Former ID
DIB007867
Drug Name
Odapipam
Synonyms
NNC 0756; NNC-756; NNC-01-0756
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 1 [546051]
Company
Novo Nordisk A/S
Formula
C19H20ClNO2
Canonical SMILES
[C@@H]1(c2c3c(ccc2)CCO3)c2c(cc(c(c2)O)Cl)CCN(C1)C
PubChem Compound ID
132421
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Antagonist [525486]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 546051Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006052)
Ref 525486PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999 May;32(2):93-109.

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