Drug Information

Drug General Information
Drug ID
D00VRV
Former ID
DIB018544
Drug Name
2-bromo-LSD
Synonyms
2-bromolysergic acid diethylamide; 2-br-LSD; bromolysergide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539779]
Formula
C20H24BrN3O
InChI
InChI=1S/C20H24BrN3O/c1-4-24(5-2)20(25)12-9-14-13-7-6-8-16-18(13)15(19(21)22-16)10-17(14)23(3)11-12/h6-9,12,17,22H,4-5,10-11H2,1-3H3/t12-,17-/m1/s1
InChIKey
VKRAXSZEDRWLAG-SJKOYZFVSA-N
PubChem Compound ID
10171
PubChem Substance ID
8157335, 16454081, 29228703, 49965381, 57326013, 77284240, 103173840, 103815006, 104021703, 104322580, 117390756, 129488766, 134973999, 135649696, 137239960, 142793122, 162219607, 198966517, 228052499, 241079990
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Antagonist [534022]
5-hydroxytryptamine 6 receptor Target Info Antagonist [533689]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
References
Ref 539779(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 272).
Ref 533689Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7.
Ref 534022Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36.

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