Drug Information

Drug General Information
Drug ID
D0N5NM
Former ID
DCL000911
Drug Name
Org-23366
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Akzo Nobel
Formula
C26H30F2N2O
Canonical SMILES
C1CCN(C1)C(=O)CCCN2CCC(=C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F<br />)CC2
InChI
1S/C26H30F2N2O/c27-23-9-5-20(6-10-23)26(21-7-11-24(28)12-8-21)22-13-18-29(19-14-22)15-3-4-25(31)30-16-1-2-17-30/h5-12H,1-4,13-19H2
InChIKey
FZWURHPZIJCZOY-UHFFFAOYSA-N
CAS Number
CAS 187673-38-7
PubChem Compound ID
9804326
PubChem Substance ID
14905053, 24112522, 44840323, 75187614, 85222549, 134339361, 135890977, 233450512, 242548484
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [536463]
D(2) dopamine receptor Target Info Antagonist [536463]
Muscarinic acetylcholine receptor M5 Target Info Antagonist [536463]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04020:Calcium signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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