Drug Information

Drug General Information
Drug ID
D0G1RT
Former ID
DIB007727
Drug Name
L-694247
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Terminated [538938], [545490]
Company
Merck & Co Inc
Formula
C20H21N5O3S
InChI
InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3
InChIKey
HKXMQLISPYELRD-UHFFFAOYSA-N
CAS Number
CAS 137403-12-4
PubChem Compound ID
132059
PubChem Substance ID
6908938, 7979695, 10243038, 11113701, 14757696, 26751890, 29310297, 47583772, 47880144, 48254008, 48404523, 53789104, 57344002, 80469584, 85209132, 85787568, 91706072, 103215944, 104376589, 126437322, 128075717, 135087434, 135650478, 135698269, 144240170, 160827894, 162022504, 163093371, 163355795, 163391346, 163842066, 171578642, 172907883, 179149884, 204366107, 206251955, 227543701, 241033641, 241181887, 242060132, 252215665, 252496692
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [533978], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 15).
Ref 545490Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003457)
Ref 533978L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol. 1993 Nov;110(3):1196-200.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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