Drug Information

Drug General Information
Drug ID
D01BPF
Former ID
DIB016206
Drug Name
Avitriptan
Synonyms
Avitriptan fumarate; BMS-180048
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 3 [545344]
Company
Bristol-Myers Squibb Co
Formula
C22H30N6O3S
Canonical SMILES
S(=O)(=O)(Cc1cc2c(c[nH]c2cc1)CCCN1CCN(c2c(OC)cncn2)CC1)<br />NC
PubChem Compound ID
133081
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [534756], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545344Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002927)
Ref 534756Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan.Cephalalgia. 1998 Oct;18(8):546-51.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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