Drug Information

Drug General Information
Drug ID
D0H3KU
Former ID
DIB018661
Drug Name
5-OH-DPAT
Synonyms
6-dipropylaminotetralin-1-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538792]
Formula
C16H25NO
InChI
InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3
InChIKey
MDBWEQVKJDMEMK-UHFFFAOYSA-N
PubChem Compound ID
172267
PubChem Substance ID
15069615, 24519959, 33496948, 50729535, 57352136, 85209658, 103172130, 103931135, 113472241, 128578360, 134347281, 135127641, 135649845, 139013574, 143218544, 226623635
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [527317]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538792(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 128).
Ref 527317Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4.

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