Drug Information

Drug General Information
Drug ID
D0E8IZ
Former ID
DIB003284
Drug Name
Tonabersat
Synonyms
SB-220453; USL-260; 5-HT1d agonist (migraine), Minster; 5-HT1d agonist (migraine), SB
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Phase 2 [522123]
Company
Upsher-smith laboratories
Formula
C20H19ClFNO4
Canonical SMILES
[C@@H]1(c2c(OC([C@H]1O)(C)C)ccc(c2)C(=O)C)NC(=O)c1cc(c(<br />cc1)F)Cl
CAS Number
CAS 175013-84-0
PubChem Compound ID
6918324
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [525903], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522123ClinicalTrials.gov (NCT00534560) Dose Ranging Study of the Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache. U.S. National Institutes of Health.
Ref 525903The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan. Cephalalgia. 2000 Jul;20(6):538-45.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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