Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06PKJ
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| Former ID |
DNC012397
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| Drug Name |
1-(2,5-dimethoxyphenyl)propan-2-amine
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| Synonyms |
2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [533498] | ||
| Formula |
C11H17NO2
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| Canonical SMILES |
CC(CC1=C(C=CC(=C1)OC)OC)N
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| InChI |
1S/C11H17NO2/c1-8(12)6-9-7-10(13-2)4-5-11(9)14-3/h4-5,7-8H,6,12H2,1-3H3
|
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| InChIKey |
LATVFYDIBMDBSY-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1D receptor | Target Info | Inhibitor | [533498] | |
| 5-hydroxytryptamine 1A receptor | Target Info | Inhibitor | [533498] | ||
| 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [529336] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| SIDS Susceptibility Pathways | |||||
| GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 529336 | Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. Epub 2008 Feb 14.The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. | ||||
| Ref 533498 | J Med Chem. 1986 Feb;29(2):194-9.5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. | ||||
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