Details of Microbe Species (MIC)

General Information of MIC (ID: MC0999)
  MIC Name
Propionibacterium acnes
  Synonym
Bacillus acnes
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinomycetia
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Cutibacterium
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Opportunist pathogen
  Genome Size (bp)
2399738
  No. of Coding Genes
1848
  No. of Non-Coding Genes
31
  No. of Small Non-Coding Genes
31
  No. of Gene Transcripts
1937
  No. of Pseudogenes 58
  No. of Base Pairs
2497951
  Description
Cutibacteria acnes is the relatively slow-growing, typically aerotolerant anaerobic, gram-positive bacteria linked to the skin condition of acne; it can also cause chronic blepharitis and endophthalmitis, the latter particularly following intraocular surgery.
  External Links Taxonomy ID 1747
Genome Assembly ID ASM344723v1
GOLD Database ID Go0543960
GIMICA ID MIC01031

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [1], [2]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [1], [2]


References
1 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
2 Propionibacterium acnes Induces Autophagy in Keratinocytes: Involvement of Multiple Mechanisms J Invest Dermatol. 2018 Apr;138(4):750-759. doi: 10.1016/j.jid.2017.11.018. Epub 2017 Nov 27.

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