Details of Microbe Species (MIC)

General Information of MIC (ID: MC0611)
  MIC Name
Shigella dysenteriae Sd197
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacteriales
Family: Enterobacteriaceae
Genus: Shigella
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Fermentative; Respiratory
  Gram
Negative
  No. of Coding Genes
4505
  No. of Non-Coding Genes
106
  No. of Small Non-Coding Genes
106
  No. of Gene Transcripts
4615
  No. of Pseudogenes 4
  Description
Shigella dysenteriae Sd197 is a strain of facultative anaerobic, gram-negative bacteria.
  External Links Taxonomy ID 300267
Genome Assembly ID ASM1200v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [3], [2]


References
1 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.

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