Details of Microbe Species (MIC)

General Information of MIC (ID: MC0572)
  MIC Name
Propionibacterium granulosum DSM 20700
  Synonym
Cutibacterium granulosum CCUG 32987, Cutibacterium granulosum CIP 103262, Cutibacterium granulosum JCM 6498, Propionibacterium granulosum ATCC 25564, Propionibacterium granulosum CCUG 32987, Propionibacterium granulosum CIP 103262, Propionibacterium granulosum DSM 20700, Propionibacterium granulosum JCM 6498
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinomycetia
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Cutibacterium
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Genome Size (bp)
2128234
  No. of Coding Genes
1953
  No. of Non-Coding Genes
43
  No. of Small Non-Coding Genes
43
  No. of Gene Transcripts
1996
  Description
Propionibacteria granulosum DSM 20700 is a strain of facultative anaerobic, gram-positive, saccharolytic bacteria.
  External Links Taxonomy ID 1160719
Genome Assembly ID PG_DSM_assembly2012

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [2], [4]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [3], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [5], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [2], [4]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.

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