Details of Microbe Species (MIC)

General Information of MIC (ID: MC0571)
  MIC Name
Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
  Synonym
Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinomycetia
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Propionibacterium
  Oxygen Sensitivity
Aerotolerant
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Probiotic
  Genome Size (bp)
2616384
  No. of Coding Genes
2375
  No. of Non-Coding Genes
51
  No. of Small Non-Coding Genes
51
  No. of Gene Transcripts
2490
  No. of Pseudogenes 64
  Description
Propionibacteria freudenreichii subsp. shermanii CIRM-BIA1 is a strain of aerotolerant, gram-positive, saccharolytic bacteria.
  External Links Taxonomy ID 754252
Genome Assembly ID ASM9172v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [2], [4]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [3], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [5], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [2], [4]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.

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