Details of Microbe Species (MIC)

General Information of MIC (ID: MC0343)
  MIC Name
Clostridium viride DSM 6836
  Synonym
Clostridium viride DSM 6836
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Non-saccharolytic
  Gram
Positive
  Genome Size (bp)
2414458
  Description
Clostridium viride DSM 6836 is a strain of obligate anaerobic, gram-positive, non-saccharolytic metabolism bacteria.
  External Links Taxonomy ID 1121344
GOLD Database ID Go0013641

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [4], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [4], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [4], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [4], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [4], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [4], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [4], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [4], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [4], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [4], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [3], [2]
           Metabolite Name: Valerate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info . . . [4], [2]
Histone Acetylation H4 EM Info . . . [4], [2]
Histone Deacetylation HDAC2 EM Info HT-29 cells . . [5], [2]
Histone Deacetylation HDAC1 EM Info HT-29 cells . . [5], [2]
Histone Deacetylation HDAC3 EM Info HT-29 cells . . [5], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
5 Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.

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