Details of Microbe Species (MIC)

General Information of MIC (ID: MC0110)
  MIC Name
Granulibacter bethesdensis
  Synonym
"Granulobacter (sic) bethesdensis" Greenberg et al. 2006
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rhodospirillales
Family: Acetobacteraceae
Genus: Granulibacter
  Oxygen Sensitivity
Aerobe
  Microbial Metabolism
Saccharolytic
  Gram
Negative
  Description
Granulibacter bethesdensis is a gram-negative, aerobic coccobacillus to rod-shaped, non-motile, catalase-positive and oxidase-negative bacteria.
  External Links Taxonomy ID 364410

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Fusobacterium periodonticum, a new species from the human oral cavity J Dent Res. 1983 Sep;62(9):960-3. doi: 10.1177/00220345830620090901.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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