Details of Microbe Species (MIC)

General Information of MIC (ID: MC0101)
  MIC Name
Dorea longicatena
  Synonym
Eubacterium sp. III-35
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Dorea
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Fermentative
  Gram
Positive
  Description
Dorea longicatena is a gram-positive, obligately anaerobic, non-spore-forming and rod-shaped bacteria from the genus of Dorea which has been isolated from human feces in Germany.
  External Links Taxonomy ID 88431
GutMDisorder ID gm0267

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces Int J Syst Evol Microbiol. 2002 Mar;52(Pt 2):423-428. doi: 10.1099/00207713-52-2-423.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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