Details of Microbe Species (MIC)

General Information of MIC (ID: MC0099)
  MIC Name
Bifidobacterium longum
  Synonym
Bifidobacterium sp. 12_1_47BFAA
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinomycetia
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Genome Size (bp)
2455762
  No. of Coding Genes
1901
  No. of Non-Coding Genes
65
  No. of Small Non-Coding Genes
65
  No. of Gene Transcripts
1966
  No. of Base Pairs
2480603
  Description
Bifidobacteria longum is a species of gram-positive anaerobic branched rod-shaped bacteria which can be found in the intestines of infant humans. They inhibit the growth of Gram-negative bacteria by producing lactic acid, and digest the complex sugars in human breast milk.
  External Links Taxonomy ID 216816
GutMDisorder ID gm0112
Genome Assembly ID ASM73020v1
GOLD Database ID Go0117415
GIMICA ID MIC00232

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community Sci Rep. 2015 Aug 28;5:13548. doi: 10.1038/srep13548.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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