Details of Microbe Species (MIC)

General Information of MIC (ID: MC0085)
  MIC Name
Klebsiella pneumoniae L5-2
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacteriales
Family: Enterobacteriaceae
Genus: Klebsiella
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Fermentative; Respiratory
  Gram
Negative
  Description
Klebsiella pneumoniae L5-2 is a strain of gram-negative, facultative anaerobic bacteria from the genus Klebsiella.
  External Links Taxonomy ID 573
GOLD Database ID Go0518795

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Complete genome sequence of acetate-producing Klebsiella pneumoniae L5-2 isolated from infant feces 3 Biotech. 2019 Mar;9(3):84. doi: 10.1007/s13205-019-1578-y. Epub 2019 Feb 15.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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