Details of Microbe Species (MIC)

General Information of MIC (ID: MC0072)
  MIC Name
Ruminococcus bromii L2-63
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
Genus: Ruminococcus
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Genome Size (bp)
2249085
  Description
Ruminococcus bromii L2-63 is an anaerobic bacteria from the species Ruminococcus bromii.
  External Links Taxonomy ID 657321
GOLD Database ID Go0004253

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [3], [4]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [4]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [4]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [3], [4]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [3], [4]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [4]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [3], [4]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [3], [4]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [4]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [3], [4]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [4]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [3], [4]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [4]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [5], [4]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Mechanistic Insights Into the Cross-Feeding of Ruminococcus gnavus and Ruminococcus bromii on Host and Dietary Carbohydrates Front Microbiol. 2018 Nov 5;9:2558. doi: 10.3389/fmicb.2018.02558. eCollection 2018.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
5 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.