Details of Microbe Species (MIC)

General Information of MIC (ID: MC0052)
  MIC Name
Moorella thermoacetica
  Synonym
Clostridium thermaceticum, Clostridium thermoaceticum
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Thermoanaerobacterales
Family: Thermoanaerobacteraceae
Genus: Moorella
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Description
Moorella thermoacetica, previously known as Clostridium thermoaceticum, is an acetogenic, thermophilic, strictly anaerobic, endospore-forming, bacteria belonging to the phylum Firmicutes.
  External Links Taxonomy ID 1525

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Homolactic Acid Fermentation by the Genetically Engineered Thermophilic Homoacetogen Moorella thermoacetica ATCC 39073 Appl Environ Microbiol. 2017 Mar 31;83(8):e00247-17. doi: 10.1128/AEM.00247-17. Print 2017 Apr 15.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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